Cancer Informatics Shared Resource (CISR)

Mission:

The mission of the Cancer Informatics Shared Resource (CISR) is to promote high quality, innovative cancer research by providing members of UW Carbone Cancer Center (UWCCC) with modern and efficient informatics, including advancements in bioinformatics, clinical informatics, image analysis and computational science.

Publications:

1. Zahm CD, Colluru VT, McIlwain SJ, Ong IM, McNeel DG. TLR Stimulation during T-cell Activation Lowers PD-1 Expression on CD8+ T Cells. Cancer Immunol Res. 2018 Nov;6(11):1364-1374. doi: 10.1158/2326-6066.CIR-18-0243. Epub 2018 Sep 10. PMID: 30201735; PMCID: PMC6215515.
2.  Rhoads TW, Burhans MS, Chen VB, Hutchins PD, Rush MJP, Clark JP, Stark JL, McIlwain SJ, Eghbalnia HR, Pavelec DM, Ong IM, Denu JM, Markley JL, Coon JJ, Colman RJ, Anderson RM. Caloric Restriction Engages Hepatic RNA Processing Mechanisms in Rhesus Monkeys. Cell Metab. 2018 Mar 6;27(3):677-688.e5. doi: 10.1016/j.cmet.2018.01.014. PMID: 29514073; PMCID: PMC5844481.
3.  Liu F, Ma F, Wang Y, Hao L, Zeng H, Jia C, Wang Y, Liu P, Ong IM, Li B, Chen G, Jiang J, Gong S, Li L, Xu W. PKM2 methylation by CARM1 activates aerobic glycolysis to promote tumorigenesis. Nat Cell Biol. 2017 Nov;19(11):1358-1370. doi: 10.1038/ncb3630. Epub 2017 Oct 23. Erratum in: Nat Cell Biol. 2017 Nov 29;19(12 ):1442. PMID: 29058718; PMCID: PMC5683091.
4.  Mehta C, Fraga de Andrade I, Matson DR, Dewey CN, Bresnick EH. RNA-regulatory exosome complex confers cellular survival to promote erythropoiesis. Nucleic Acids Res. 2021 Sep 20;49(16):9007-9025. doi: 10.1093/nar/gkab367. PMID: 34059908; PMCID: PMC8450083.