SMPH Shared Resources
School of Medicine and Public Health

Small Molecule Screening Facility (SMSF)֍

This is an accordion element with a series of buttons that open and close related content panels.

Mission

The Small Molecule Screening Facility (SMSF) fosters collaborative drug discovery research between chemists, biologists and physician scientists that leads to the identification of new small molecules that inhibit disease targets and phenotypes in biochemical and cellular models relevant to any therapeutic area.

Contact

Facilities

Rigor and Reproducibility

Letter of Support

  • Letter of Support Template
    Word        PDF

This is an accordion element with a series of buttons that open and close related content panels.

Publications

  1. Zhang F, Zhao M, Braun DR, Ericksen SS, Piotrowski JS, Nelson J, Peng J, Ananiev GE, Chanana S, Barns K, Fossen J, Sanchez H, Chevrette MG, Guzei IA, Zhao C, Guo L, Tang W, Currie CR, Rajski SR, Audhya A, Andes DR, Bugni TS. A marine microbiome antifungal targets urgent-threat drug-resistant fungi. Science. 2020 Nov 20;370(6519):974-978. doi: 10.1126/science.abd6919. PMID: 33214279; PMCID: PMC7756952.
  2. Liu WH, Miner RE 3rd, Albaugh BN, Ananiev GE, Wildman SA, Denu JM. Discovery and Mechanism of Small Molecule Inhibitors Selective for the Chromatin-Binding Domains of Oncogenic UHRF1. Biochemistry. 2022 Mar 1;61(5):354-366. doi: 10.1021/acs.biochem.1c00698. Epub 2022 Feb 10. PMID: 35143176; PMCID: PMC9190237.
  3. Yan JX, Wu Q, Helfrich EJN, Chevrette MG, Braun DR, Heyman H, Ananiev GE, Rajski SR, Currie CR, Clardy J, Bugni TS. Bacillimidazoles A-F, Imidazolium-Containing Compounds Isolated from a Marine Bacillus. Mar Drugs. 2022 Jan 1;20(1):43. doi: 10.3390/md20010043. PMID: 35049898; PMCID: PMC8779896.
  4. Wheeler NJ, Ryan KT, Gallo KJ, Henthorn CR, Ericksen SS, Chan JD, Zamanian M. Multivariate chemogenomic screening prioritizes new macrofilaricidal leads. Commun Biol. 2023 Jan 13;6(1):44. doi: 10.1038/s42003-023-04435-8. PMID: 36639423; PMCID: PMC9839782.
  5. Yu P, Ericksen S, Gitter A, Newton MA. Bayes optimal informer sets for early-stage drug discovery. Biometrics. 2022 Feb 15:10.1111/biom.13637. doi: 10.1111/biom.13637. Epub ahead of print. PMID: 35165892; PMCID: PMC9376199.

֍ This core facility utilizes iLab, an online management tool that allows researchers to request services, schedule equipment and manage billing with UW shared resources.