SMPH Shared Resources
School of Medicine and Public Health

Electron Microscope (EM) Facility

This is an accordion element with a series of buttons that open and close related content panels.

Mission

It is the mission of the University of Wisconsin School of Medicine and Public Health Electron Microcopy Core Facility to provide exceptional scientific research and service to users from within the university system and around the nation. We are a full-service facility that delivers high quality and skilled sample preparation and electron imaging services to campus users and community partners. Our work supports research grants and programs that are vital to the advancement of the university’s biological, clinical and chemical research.

Contact

Facilities

Rigor and Reproducibility

  • R&R Statement
    Word        PDF

Letter of Support

  • Letter of Support Template
    Word        PDF

This is an accordion element with a series of buttons that open and close related content panels.

Publications

  1. Resende MT, August BK, Radecki D, Reilly M, Komro A, Heidari M, Svaren J, Anaby D, Duncan ID, Cohen Y. QSI and DTI of inherited white matter disorders in rat spinal cord: Early detection and correlation with histology.
  2. Saha A, Capowski E, Zepeda MAF, Nelson EC, Gamm DM, Sinha R. Cone photoreceptors in human stem-cell derived retinal organoids demonstrate intrinsic light responses that mimic those of primate fovea.  Cell Stem Cell. 2022 Mar 3;29(3):460-471.e3. doi: 10.1016/j.stem.2022.01.002. PMID: 35104442 PMCID: PMC9093561.
  3. Simonson L, Vold S, Mowers C, Massey RJ, Ong IM, Longley BJ, Chang H. Keratin 13 deficiency causes white sponge nevus in mice. Dev Biol. 2020 Dec 1;468(1-2):146-153. doi: 10.1016/j.ydbio.2020.07.016. Epub 2020 Aug 3. PMID: 32758484; PMCID: PMC7669562.
  4. Alperstein AM, Molnar KS, Dicke SS, Farrell KM, Makley LN, Zanni MT, Andley UP. Analysis of amyloid-like secondary structure in the Cryab-R120G knock-in mouse model of hereditary cataracts by two-dimensional infrared spectroscopy. PLoS One. 2021 Sep 14;16(9):e0257098. doi: 10.1371/journal.pone.0257098. PMID: 34520490; PMCID: PMC8439473.
  5. Pennati A, Nylen EA, Duncan ID, Galipeau J. Regulatory B Cells Normalize CNS Myeloid Cell Content in a Mouse Model of Multiple Sclerosis and Promote Oligodendrogenesis and Remyelination. J Neurosci. 2020 Jun 24;40(26):5105-5115. doi: 10.1523/JNEUROSCI.2840-19.2020. Epub 2020 May 19. PMID: 32430295; PMCID: PMC7314404.
  6. Knowles S, Leis EM, Richard JC, Cole R, Agbalog RE, Putnam JG, Goldberg TL, Waller DL. A Novel Gonadotropic Microsporidian Parasite (Microsporidium clinchi n. sp.) Infecting a Declining Population of Pheasantshell Mussels (Actinonaias pectorosa) (Unioinidae) from the Clinch River, USA. Parasitologia. 2022; 2(1):1-12. doi: 10.3390/parasitologia2010001.
  7. Tremmel DM, Sackett SD, Feeney AK, Mitchell SA, Schaid MD, Polyak E, Chlebeck PJ, Gupta S, Kimple ME, Fernandez LA, Odorico JS. A human pancreatic ECM hydrogel optimized for 3-D modeling of the islet microenvironment. Sci Rep. 2022 May 3;12(1):7188. doi: 10.1038/s41598-022-11085-z. PMID: 35504932; PMCID: PMC9065104.
  8. Wilson CL, Hung CF, Burkel BM, Ponik SM, Gharib SA, Schnapp LM. Nephronectin is required to maintain right lung lobar separation during embryonic development. Am J Physiol Lung Cell Mol Physiol. 2023 Mar 1;324(3):L335-L344. doi: 10.1152/ajplung.00505.2021. Epub 2023 Jan 31. PMID: 36719987; PMCID: PMC10027138.
  9. Chang CW, Hsiao YT,  Jackson MB. Synaptophysin Regulates Fusion Pores and Exocytosis Mode in Chromaffin Cells Journal of Neuroscience 21 April 2021, 41 (16) 3563-3578; doi: 10.1523/JNEUROSCI.2833-20.2021.
  10. Dhillon RS, Qin YA, van Ginkel PR, Fu VX, Vann JM, Lawton AJ, Green CL, Manchado-Gobatto FB, Gobatto CA, Lamming DW, Prolla TA, Denu JM. SIRT3 deficiency decreases oxidative metabolism capacity but increases lifespan in male mice under caloric restriction. Aging Cell. 2022 Dec;21(12):e13721. doi: 10.1111/acel.13721. Epub 2022 Oct 5. PMID: 36199173; PMCID: PMC9741511.
  11. de Lange WJ, Farrell ET, Kreitzer CR, Jacobs DR, Lang D, Glukhov AV, Ralphe JC. Human iPSC-engineered cardiac tissue platform faithfully models important cardiac physiology. Am J Physiol Heart Circ Physiol. 2021 Apr 1;320(4):H1670-H1686. doi: 10.1152/ajpheart.00941.2020. Epub 2021 Feb 19. PMID: 33606581; PMCID: PMC8260387.
  12. Block LN, Schmidt JK, Keuler NS, McKeon MC, Bowman BD, Wiepz GJ, Golos TG. Zika virus impacts extracellular vesicle composition and cellular gene expression in macaque early gestation trophoblasts. Sci Rep. 2022 May 5;12(1):7348. doi: 10.1038/s41598-022-11275-9. PMID: 35513694; PMCID: PMC9072346.
  13. Kasberg W, Luong P, Hanna MG, Minushkin K, Tsao A, Shankar R, Block S, Audhya A. The Sar1 GTPase is dispensable for COPII-dependent cargo export from the ER. Cell Rep. 2023 Jun 9;42(6):112635. doi: 10.1016/j.celrep.2023.112635. Epub ahead of print. PMID: 37300835.
  14. Horton MV, Johnson CJ, Zarnowski R, Andes BD, Schoen TJ, Kernien JF, Lowman D, Kruppa MD, Ma Z, Williams DL, Huttenlocher A, Nett JE. Candida auris Cell Wall Mannosylation Contributes to Neutrophil Evasion through Pathways Divergent from Candida albicans and Candida glabrata. mSphere. 2021 Jun 30;6(3):e0040621. doi: 10.1128/mSphere.00406-21. Epub 2021 Jun 23. PMID: 34160238; PMCID: PMC8265655.